Tumours, masses and neoplasia
Retinoblastoma (for Part 2)
Retinoblastoma
- 1:20,000
- Arises from embryonal retinal cells (primitive retinoblasts)
- Loss of function of the Rb tumour suppressor gene (Chromosome 13q14)
- F=M
Genetics
Hot Topic
Retinoblastoma genetics is a very popular exam topic!
Knudson’s two hit hypothesis, via:
- Genetic/germline/hereditary form: every cell is…