Retinitis Pigmentosa

• Heterogenous group of rod-cone dystrophies
• Commonest inherited retinal disease
• Varying clinical appearances due to varying inheritance patterns

Genetics

• 20% autosomal dominant: later onset, less severe

• 20% autosomal recessive

• 8-25% X-linked recessive: most severe

• 20-25% isolated (unidentifiable inheritance pattern)

• 50% have…