Physiology

Physics Of Blood Flow

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  • Velocity is inversely proportional to the cross-sectional area at that point in a system of tubes

  • Eg. velocity is higher in the aorta than in capillaries (which in total have a much larger cross-sectional area)

  • Resistance is
    • Inversely proportional to the radius of the vessel to the fourth power
    • Directly proportional to the length of the vessel
    • Directly proportional to the pressure gradient along the vessel
    • Dependent on the viscosity of blood (ie. haematocrit)
  • Blood pressure = cardiac output x peripheral resistance
  • Cardiac output = heart rate x stroke volume

Hot Topic

Starling’s Law: force of contraction proportional to the initial length of the muscle

  • Increased preload will increase myocardial stretch and increase stroke volume
  • Afterload initially causes reduced stroke volume due to increased resistance

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