Pharmacology
G-Proteins
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Get access- Mediate the effects of receptor-ligand interactions
- Membrane-bound proteins
- Three subunits
- Alpha: GTPase
- Beta and gamma: attach the protein to the membrane
- The alpha subunit dissociates on binding of an agonist and converts GTP to GDP
- A single agonist ligand can activate numerous G-proteins, leading to signal amplification
- Examples
- Muscarinic acetylcholine receptors
- Adrenergic receptors