Physiology
Accomodation
- Zonules control accommodative movement of the ciliary muscle upon the lens
Ciliary muscle comprises three groups of smooth muscle fibre bundles which function with the zonules and the elastic lens capsule to alter the refractive power of the lens
Hot Topic
“Near triad”: accommodation, pupillary constriction, convergence
- Not a true reflex
- Accommodation is the slowest part
Note: if accommodation is prevented (eg. using a refracting lens) convergence will still be associated with pupillary constriction
Development
- Accommodation begins to develop at 2 months of age
- Well developed by 8 months
- 2 year old: 20 dioptres
- 20 year old: 10 dioptres
- 60 year old: no or little accommodation (<2 dioptres)
Clinical Correlate
Adie’s pupil: damage to ciliary ganglion may cause loss of accommodation
Lens component
- Anterior radius of curvature (10mm) is larger than the posterior (6mm)
- These values change as the lens enlarges with age.
Accommodative power decreases with age: approximately 14 dioptres at 10 years becomes 10 dioptres at 20 years
- The nucleus has greater refractive index (1.406) than the cortex (1.386)
- Lens capsule contracts during accommodation
- Anterior pole moves anteriorly
- Axial width increases
- Equatorial diameter decreases
- Lens moves with gravity
- Lens capsule
- Variable thickness: poles are thinner than the equator
- Elastic: changes shape passively in response to CB contraction
- Diabetic patients have a more fragile capsule
Note
Lens capsule antigens are similar to those in the glomerular basement membrane
Ciliary muscle component
- Smooth muscle
- Contracts and reduces tension on the zonular fibres
Mostly longitudinally arranged fibres forming a circle with some passing to anterior choroid
- Oblique fibres attach to the scleral spur
Clinical Correlate
Muscarinic agonists (eg pilocarpine) act on the ciliary muscle to produce accommodation, anterior pull on the choroid and traction on the trabecular meshwork fibres via the scleral spur to aid aqueous outflow
AC:A ratio
- The number of prism dioptres of convergence induced by each dioptre of accommodation
- Normal range is 3:1 to 5:1
- Can be altered
- Optically: glasses
- Medially
- Surgically
- Heterophoria method
- AC:A = IPD in cm + (Near PCT)-(Distance PCT)Near fixation distance in dioptres
Note: PCT values are positive for esodeviations (convergences) and negative for exodeviations (divergences)
- Uses the changes in deviation for near versus distance
- Gradient method
- Uses measurements at the same distance but induces accommodative changes using lenses
- Does not require the IPD
AC:A = Deviation when accommodation greatest - Deviation when accommodation leastAmount of accommodation in dioptres
- Distance-near comparison
- Simpler, quicker, no calculations
- Compare the deviation at distance with that for near
- If the near deviation is >10PD more, the AC:A is likely abnormally high
- Fully refractive/accommodative esotropia can be eliminated by glasses wear.
If an esotropia is reduced but not eliminated by hypermetropic correction then squint surgery may be needed in addition to glasses
- See Part 2 package for full chapters on strabismus
Zonular fibres
- Radially arranged zonules of Zinn
- Attached 2mm anterior and 1mm posterior to lens equator
- Bundles of fine fibres composed of microfibrils
- Composed principally of fibrillin (cysteine-rich glycoprotein)
- Fibrillins form the structural scaffold of extensive microfibrils
- Provide strength and elasticity to ocular connective tissues
- Synthesised by non-pigmented ciliary epithelium
- Emerge from basal lamina of epithelium and insert beneath the lens capsule
- Pass from ciliary processes to lens and do not cross each other
- Others form part of the vitreous base
Clinical Correlate
Homocystinuria causes lens dislocation because zonules are cysteine rich