Genetics

Genomic Imprinting

  • The difference in phenotypic expressions depending on the origin (paternal or maternal) of the disease chromosome
  • Deletion of paternally derived 15q12 results in Prader-Willi syndrome
    • Feeding problems
    • Small hands and feet
    • Hypogonadotrophic hypogonadism
    • Cryptorchidism
    • Obesity 
  • Deletion of maternally derived 15q12…
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Proto-Oncogenes and Oncogenes