Pharmacology
Intravitreal Anti-VEGF
- CNVM and DMO are driven by upregulation of pro-angiogenic growth factor: vascular endothelial growth factor (VEGF)
- From platelet-derived growth factor family
- Breaks down the inner blood-retinal barrier
- Increases capillary permeability
- Upregulated in hypoxia via hypoxia inducible factor (HIF)
- Anti-VEGF therapies…